Anyone who has ever read neurologist Oliver Sacks' classic essay collection 'The Man Who Mistook His Wife for a Hat' might wonder about the downsides of having a protein nanowire brain extension. The lesson from the book is that small changes to the brain can have enormous consequences for consciousness and our experience of reality.
Who knows? Perhaps it might be like a permanent magic mushroom trip where you can see and talk to interdimensional machine elves, and that would be an upside for some people.
This expands the range of 'Work From Home' to include physical labor. Humanoid robots aren't far off the point (2030s?) where they can do most unskilled labor. With telepresence, they can take those jobs sooner.
This also brings something else closer. The looming crisis over what our governing economic model will be when human labor can no longer compete for wages with AI & robots.