Futurology

I'm skeptical. Anything targeting signalling pathways seems likely to have consequences that aren't apparent from animal trials. I remember a few years back that MENT (trestolone, 7α-methyl-19-nortestosterone) was being investigated for use as male contraceptive, and one of the biggest issues I recall was that it caused really wild mood swings in a number of men. Admittedly, MENT is hormonal, but I don't think that issues it caused were anticipated; I think the profile looked much more promising than it ended up being.