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I suggest you tell her that this is a problem, and that this is affecting your friendship. That if she does not try to educate herself, that you will have to reconsider the friendship.
Tell her that trans people have something called gender dysphoria. Reference Wikipedia and DSM. Prove that this is a real thing. Just like her autism. The best would probably be to just send her a couple of links with a short, but honest take on how this is a problem for you. Let her read it herself om her own time.
The last thing you should do is let the friendship end without talking to her. Its important to confront people, and give them a chance to change their mind. People deserve that.