That's not why she lost. The sexist vote is going to go Republican, regardless of what Democrat is running. Whatever votes she might have lost because of her gender would be made up for with enthusiasm for the first woman president, if only she was someone who could inspire enthusiasm.
Too bad the Democrats didn't make the election a referendum on the healthcare system. It suddenly seems like that's what the "moderate" voters she was going for actually care about. Someone should have suggested that.
The ACA made the Health insurance industry into one of the biggest profit generating machines in the country. That brought in the Wall Street greed machine and tons of lobbying cash. Now it's entrenched and the Democrats are afraid to touch it.
The ACA brought in some much needed reforms, but the cost we paid might mean the collapse of the whole system. It was another massive cash transfer to the wealthy at a time when wealth inequality was already out of control. Once that cash starts flowing, shutting off the taps takes backbone, and most Democrats don't have those. Wall Street now feels entitled to those earnings forever.