I said Noita is my favourite roguelite, but actually Heat Signature is probably tied with it. It has a completely different philosophy of soft failure.
If your character dies in space, they're dead, but they can also be captured, then another character can rescue them. And if a mission is going sideways, you can huck a wrench through a window and fling yourself into space, as long as you're confident you can pick yourself up with your space pod before you pass out.
It's very fast-paced with quick runs. Each character that comes along has different traits, and you can have 4 different people on the go at once. Each character has their individual quest - which can be rescuing another character - and when that's done you can retire them or keep them going.
It's very open to how you want to play.
Oh! Also, if you're trying to do your character's big final mission and it goes wrong, usually you can bail and try again. I lost quite a few characters before I realised that.