I never played HotS but I played Dota 1&2 for many years. Recalibrating for Deadlock hasn't been easy, despite being familiar with stuff like last hitting.

The farm thing is what stands out to me most, as you can't really play passively if you feel like you're outmatched skill-wise in Deadlock. In something like TF2 or Overwatch you can play more defensively if you feel disadvantaged, but here what will happen is you'll fall so far behind on farm you'll never be able to contribute.

The map feels too small and the pace too high, somehow, and 4 lanes seem too many. It's been hard to feel like you can leave your lane and gank without opening too much of a vulnerability on your "home" lane. This exacerbates the problem of one lane getting stomped and that snowballing into an unstoppable victory.

It's very possible all these problems diminish with good team play, though. This might be one of those games you can't enjoy properly without organised team play and active voice comms.