PEAR? Where staff participated in trials, rather than doing double blind experiments? Whose results could not be reproduced by independent research groups? Who were found to employ p-hacking and data cherry picking?
You might as well argue that simulating a human mind is not possible because it wouldn't have a zodiac sign.
Counterpoint, from a complex systems perspective:
We don't fully know or are able toodel the details of neurochemistry, but we know some essential features which we can model, action potentials in spiking neuron models for example.
It's likely that the details don't actually matter much. Take traffic jams as an example. There is lots of details going on, driver psychology, the physical mechanics of the car etc. but you only need a handful of very rough parameters to reproduce traffic jams in a computer.
That's the thing with "emergent" phenomena, they are less complicated than the sum of their parts, which means you can achieve the same dynamics using other parts.
There is this one YT Series "Jet Lag" where three guys play catch in Europe using Trains. It's a lot of planning, checking what the travel options of the hunted one are, which trains he might take etc. It's a game of strategy, until they arrive in Germany at which point it litteraly becomes a clusterfuck of random trains.
You shouldn't open the URL, but you can scan it to see if a url is recognized
it can be recognizable as a qr code, but still fail to scan for an app. Moreover, because you are using much of the redundancy of the qr code, you have to limit the amount of information in it. That's why the working ones that you find on the internet only have shortened URLs they point to. It doesn't work for more complicated information.
How about AI generated Animes? Corridor Crew also published video with in depth explanations on what they did, and I think even published tutorials
Yes the connectome is kind of critical. But other than that, sub threshold oscillations can and are being modeled. It also does not really matter that we are digitizing here. Fluid dynamics are continuous and we can still study, model and predict it using finite lattices.
There are some things that are missing, but very clearly we won't need to model individual ions and there is lots of other complexity that will not affect the outcome.