I got myself a vertical mouse and no longer grind down my wrist on the table. Definitely worth every penny.
I used to have the Microsoft Explorer mouse which is a bit larger, I used it for over 5 years per mouse. The old version is no longer available and the new one looked terrible, that got me into looking for alternatives in the first place.
But if you're okay with the default mouse sizes and don't have other issues they are fine too.
As some who has played maybe 30-50% of DOS1+2 and currently the first of three acts in BG3: If you have issues with the gameplay mechanics in DOS1/2 you'll likely have them in BG3 too. Main difference is a vastly improved storyline, which kinda makes up for most of them.
Issues I still have with BG3 boils down to only the active character can use its abilities in conversations and sometimes (mechanically) unexpected stuff happens that can only be undone by saves.
If your issue with DOS was a boring story and lack of hidden/funny things to uncover you should give BG3 a try, if you disliked the overall experience you likely won't enjoy BG3.