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              FTC’s click-to-cancel rule has been struck down by federal judges at the eleventh hour
 
            
            (www.engadget.com)
          
          This is a most excellent place for technology news and articles.
Likely not. Many times the address doesn’t even have a mailbox, so it immediately bounces. If you reply enough to actually have an effect, you’ll either be blacklisted, or reported as spam.