The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
We should absolutely not turn to defederation as a first action. You know how traditional social media bans opinions that are not acceptable according to themselves?
We must be better than that. It creates a ridiculous otherwise where people think everyone agrees with them and they are never challanged in how they think about things.
I think we should be exposed to different opinions as long as it's within the rules, meaning people must be polite, not hateful, not breaking the law etc.