this post was submitted on 07 Feb 2024
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Those sequences do things and have effects. In fact, the coding regions are often less functional than the non-coding ones.
Sometimes they ARE there for structural reasons? Read: enhancers, or CTCF binding sites? Among many other myriad examples of functional noncoding regions? Also, nucleotides =/= codons. There are 64 codons.
That's bull. You're out of your depth. A contemporary college molecular biology course would show your examples to the contrary.
I feel like a broken record but Enhancers! lncRNAs! siRNAs! Binding sites! Other gene regulatory regions! Epigenetic nucleosome modifications! Chromatin remodeler sites!
Oh, there's your problem. A lot has changed. You refuse to see the sea change happening around you because it means you're out of date.
I was happy to reply to you and engage pleasantly originally but you are only engaging with people that know less about biology than you do. You are not an expert if you last studied biology decades ago and can't remember the details. You certainly aren't enough of an authority on the subject to question a contemporary article published in Science or the work of other researchers currently in the field.
I really, really encourage you to read these papers thoroughly. You are the target audience-- people who learned the machine model of the cell and who are gripping it so tightly that they are blind to the nuance that we've uncovered. I also encourage you to not write insults about people who disagree with you, especially people with more domain knowledge than you have.
Every sperm isn't sacred and every piece of DNA isn't with purpose, otherwise explain ferns and plants having hundreds of times more DNA than higher functioning life forms.