uuldika

the 8bit FOX interview with Tucker Carlson felt incredibly on theme. you could seriously remake Papers, Please with these aesthetics.

I'm a big fan and longtime reader of Derek Lowe. He called attention to suppression of grant funding for hypotheses that challenged the amyloid hypothesis, and the shockingly partisan and dogmatic behavior of journal referees and NIH advisors in the field. I've been following his coverage ever since he started reporting disappointing readouts from clinical trials on the anti-amyloid mABs.

His concern that this class of therapy is "pathological science" (think cold fusion, or EmDrive, or string theory - not outright quackery, but hypotheses that are endlessly tweaked to justify the latest failures) are valid.

However, the newest mABs really do seem to have a small but statistically significant effect on slowing disease progression. Enough to justify the risks of brain swelling? Or the cost? Probably not. But I think Derek has perhaps swung too far in the opposite direction. It's too early to call time on this therapeutic target. If it's marginally but truly effective, we should try to figure out why, and keep tweaking the drugs to see if they can be improved.

Donepezil was a dead end, but it's too early to say if Aduhelm is too.

weeds are to gardens like my house is to HOAs.

So tired of hearing that the right is a champion of free speech.

The idea that, if all Trump supporters simply had access to better information, if they all had better education, if they were exposed to the right argument... then they'd see the light and turn into democrats - is a supremely liberal idea. We need to understand that no amount of epic slams, no amount of late night talk show roasts, no amount of facts and logic will steer us out of fascism.

Well said. And honestly, it's even counterproductive, because that assumption is a core reason why people view the establishment Left as patronizing and elitist.

It also reminds me of one of my favorite Onion videos: https://youtu.be/lpzVc7s-_e8 (I like Judith Butler, and I've even read some of Gender Trouble, but the premise and execution just gets me in stitches every time.)

nix collect-garbage, comrade! there's also another command to clean up older generations. if you're using git to version your nix config, you only really need to keep two generations: the current, and your last successful boot, since you can recover by git checkout.

look into NixOS! there might already be a package for it. and NixOS can be very good about not duplicating dependencies.

is this... somehow... real?

could you make this?

Friendship ended with nuclear non-proliferation. Now nuclear proliferation is my best friend.

Lockpicks. One day the bathroom door somehow locked from the inside without anyone in there, and I really needed to pee. Really came in handy. ~~Turns out you could just use a flathead screwdriver, there wasn't an actual lock cylinder, but don't take this from me!~~

I've literally read the code for Signal's double-ratchet protocol. It's extremely high quality cryptography, written in Rust, open source, with several independent audits.

The server code isn't open, but we know they (used to?) use Intel SGX enclaves so the contact metadata is sealed from even the Signal Foundation. Admittedly SGX fell prey to a number of speculative execution attacks, but Signal had no way of foreseeing that.

Also, Moxie hasn't been involved since 2022.

What on Earth does Signal requiring phone numbers have to do with Israel?