Humans will be so different from life in space that they will be unable to communicate with it.
So glad that there are sci-fi authors out there who actually put some thought into just how alien aliens would be. Even in some really good sci-fi, the differences between humans and various alien species seems to be, at most, some distinctive biological differences and cultural differences that can be conceptualized relatively easily by humans.
I reckon that the universe is vast and unknown enough that "life" could arise such that humans wouldn't be able to recognize or characterize it as life.