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Off the top of my head, I don't think I have watched any shows that feature a character that uses a wheelchair (in a realistic setting anyway). The only example I can think of that prominently features a wheelchair user as a character is "Josee, the Tiger and the Fish" which I haven't seen. Scrolling through the disability tag on AniList doesn't really help me find any other examples either.
Are there other instances that people know of?
.Dot/hack
But it's only relevant in hindsight.
Nunnally from Code Geass came to mind... but then again you said realistic setting so she probably doesn't qualify.
Ah, that is one I should have thought of, but yeah, like you said not really what I had in mind with the question. I just find it interesting that wheelchair bound characters are not typically depicted in anime/manga very much (or Western media either for that matter). In doing some quick searching, I found that Anime-Planet has a tag for it in their database, but a lot of the characters I see in the list are only temporarily in a wheelchair, or are characters confined to a hospital due to some condition (or are from series that I haven't seen, so I can't really say). In any case, just something that was on my mind from the visual.
the proportions are so weird
Blonde is wearing Shadow's sneakers.