I think it's dark matter. There are so extremely many theories around it and it's very hard to measure experimentary.
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How to accurately estimate signal crosstalk and power delivery performance without FEM/MoM simulators.
For people and companies that can't afford 25k-300k per year in licence and compute costs, there is yet to be a good standard way to estimate EM performance. Not to mention dedicated simulation machines needed.
That's why these companies can charge so damn much. The systems are so complex that making a ton of assumptions to pump out some things by hand or with bulk circuit simulators often doesn't even get close to real world performance.
If someone figured out an accurate method without those simulations, the industry could also save a shit ton of compute power and time.
Origin of life matters to a lot of people I think. RNA vs other self-replicating molecules? Moon-based tidal PCR? Cell formation etc.